BackgroundFew studies have examined factors associated with willingness of people living with HIV to participate in HIV treatment clinical trials in Sub-Saharan Africa. We assessed the factors associated with participation of PLHIV in HIV treatment clinical trials research at a large urban clinical and research facility in Uganda.MethodsA mixed methods study was conducted at the Infectious Diseases Institute, adult HIV clinic between July 2016 and January 2017. Data were collected using structured questionnaires, focused group discussions with respondents categorised as either (...) participated or never participated in clinical trials and key informant interviews with IDI staff. A generalized linear model with a logit link function was used for multivariate analyses while the qualitative data were summarized using a thematic approach.ResultsWe enrolled a total of 202 and analysed 151 participants, 77 of whom were male with mean age of 41 years. The majority 127 expressed willingness to participate in treatment clinical trials if given an opportunity. At bivariate analysis, willingness to participate was significantly associated with respondents’ perception of a satisfactory compensation package, special status accorded and belief that their health status would improve while on the clinical trial. At multivariate analysis, a satisfactory compensation package and special status accorded in clinical trials remained significant. The qualitative data analysis confirmed these findings as participants valued the privilege of jumping the clinic waiting queues and spending less time in clinic, the wide range of free tests offered to trial participants, unrestricted access to senior physicians and regular communication from study team. Additionally, free meals offered during clinic visits meant that participants were not in a hurry to go back home. Barriers to participation included the perception that new drugs were being tested on them, fear of side effects like treatment failure and the uncertainty about privacy of their data.ConclusionWe found overwhelming willingness to participate in HIV treatment clinical trials. This was largely extrinsically influenced by the perceived material and health-related benefits. Investigators should pay attention to participants’ concerns for benefits which may override the need to understand study procedures and risks. (shrink)

This essay first contextualizes Adorno's essays in literary criticism in relation to his historico‐philosophical account of modern rationalization and late capitalism, his dialectical theory of culture, and his return to postwar Germany. It then presents the neo‐Marxist and formalist principles that inform his literary criticism, emphasizing the artwork's critical relationship to society, on the one hand, and the theory of aesthetic experience undergone by the artwork's recipient on the other. These principles are exemplified in selective readings of Adorno's essays on (...) Heinrich Heine and Friedrich Hölderlin. The essay concludes by polemically juxtaposing Adorno's practice of literary criticism with that of neo‐Aristotelian “ethical criticism.”. (shrink)

_Critical Models_ combines into a single volume two of Adorno's most important postwar works -- _Interventions: Nine Critical Models_ and _Catchwords: Critical Models II_. Written after his return to Germany in 1949, the articles, essays, and radio talks included in this volume speak to the pressing political, cultural, and philosophical concerns of the postwar era. The pieces in _Critical Models_ reflect the intellectually provocative as well as the practical Adorno as he addresses such issues as the dangers of ideological conformity, (...) the fragility of democracy, educational reform, the influence of television and radio, and the aftermath of fascism. This new edition includes an introduction by Lydia Goehr, a renowned scholar in philosophy, aesthetic theory, and musicology. Goehr illuminates Adorno's ideas as well as the intellectual, historical, and critical contexts that shaped his postwar thinking. (shrink)

This is an exploration of what Locke and Whately said about the Argumentatum ad Hominem, especially in the context of what they said about the other ad arguments, and with a view to ascertaining whether what they said lends support to the understanding of this argument implicit in Johnstone's thesis that all valid philosophical arguments are ad hominem. It is concluded that this support is forthcoming insofar as Locke and Whately had in mind an argument concerned with principles.The essay ends (...) with a brief reformulation of Johnstone's generalization regarding philosophical arguments. (shrink)

_Philosophy and Argument_ presents systematic analysis of the role of argumentation in philosophy.

In lieu of an abstract, here is a brief excerpt of the content:The Philosophical Basis of RhetoricHenry W. JohnstoneI want to begin by distinguishing between what has a philosophical basis at all and what has none. Science, history, morals, and art have a philosophical basis. Fishing, tennis, needlecraft, and carpentry do not. The criterion that determines membership in each list is simple: an activity has a philosophical basis if, and only if, the practice of it distinguishes man from the animals. (...) It must be disqualified on the ground that some animals, as well as men, fish. It might be argued, however, that there is an art of fishing requiring tools utilizable by man alone, and that the ability to fish in this way distinguishes man form the animal. To be sure, in some cultures fishing with appropriate tools is necessary. In others, carpentry is. But if we came across a culture in which fishing did not occur, we would not say, "This creature does not fish; hence he is not a man'; and the same for carpentry. It may seem that the same question arises for science and history. Not all cultures are scientific. If science is indeed, as I maintain, necessary for men, what then prevents us from visiting some primitive tribe and saying, "These creatures have no science; hence they are not men"? The answer is that the culture we have encountered is prescientific. Even though its participants have at the moment no science, science is somehow "in the cards" for them. We would not characterize the nomads of Afghanistan as being in a pre-fishing era. We would not say that fishing was in the cards for them. Of course if the desert should become a sea, they will become fishermen, and there will have been a pre-fishing era. But it is not necessary to the character or status of the nomad that he represent either a pre-fishing or a fishing, or, for that matter, a post-fishing era. It is not necessary for man, however, that he be either prescientific man or scientific man or postscientific man. I add the last rubric to accommodate not only the tragic possibility of a cataclysm that could wipe out all humans capable of maintaining the tradition of science but also the ironic possibility that man might some day simply turn away from science. In either eventuality, man would be essentially characterized as a being living in a [End Page 15] postscientific era; that is, not merely as a being bereft of science, but as a being living a life either oriented to the cataclysm that had shattered the tradition of science or else oriented to the conviction that science is a thing of the past. The non-fishing nomad, on the other hand, need not take any position at all with regard to the nature or value of fishing. The possibility of fishing need receive no mention in any characterization of him.The principle I have roughly stated and exemplified implies that if rhetoric has a philosophical basis, it is necessary to man, in the sense that all men live in either a pre-rhetorical culture, or a rhetorical culture, or a post-rhetorical culture. Each of these cultures is characterized by a disposition toward rhetoric. In the pre-rhetorical era, even though man does not engage in any form of rhetoric that we can recognize, we can see rhetorical activity as in the cards for him. Perhaps someone will object that there never has been such an era; as long as man has existed, he has engaged in rhetoric. So much the better for my argument; for then it is all the more clearly the case that rhetoric is necessary to man. But if man has gone through a pre-rhetorical phase, he is distinguished form all nonhuman creatures in this respect. No one would say of rats, cats, or cows that they are not yet engaged in rhetoric, but that once the idea occurs to them they will be. But man is either rhetorical from the outset or fated to become so once a certain idea dawns upon him—this, at any rate, is what anyone would be claiming who asserted that rhetoric has a... (shrink)

On Death, by the Epicurean philosopher Philodemus of Gadara, is among the most significant philosophical treatments of the theme surviving from the Greco-Roman world. The author was an influential figure in first-century B.C.E. Roman society, associated with poets such as Virgil and politicians such as the father-in-law of Julius Caesar. The surviving copies of his treatises were carbonized following the eruption of Vesuvius in 79 C.E. This edition contains the Greek text, newly reconstituted with the help of the infrared imaging (...) technology that has revolutionized the study of Philodemus’s works in the twenty-first century, and completely translated into English for the first time. An extensive introduction provides background on Philodemus and his writings, accompanying notes enrich the text, and forty-four pages of photographs illustrate the papyrus manuscript from which the translation is drawn. (shrink)